Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 378, Issue 1, Pages 1-5Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2008.10.146
Keywords
Osteoclast; NF-kappa B; Canonical pathway; Non-canonical pathway
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NF-kappa B is a pleiotropic transcription factor, which-regulates osteoclast formation, function, and survival. The finding that the deletion of both NF-kappa B p50 and p52 subunits resulted in osteopetrosis due to the absence of osteoclasts was followed by the observation that NF-kappa B is essential for RANK-expressing osteoclast precursors to differentiate into TRAP+ osteoclasts in response to RANKL and other osteoclastogenic cytokines. Thus, inhibitors of NF-kappa B should prevent osteoclast formation induced directly or indirectly by RANKL or TNF. In this mini review, we discuss the research findings that revealed essential roles of NF-kappa B signaling in osteoclasts. (C) 2008 Elsevier Inc. All rights reserved.
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