Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 386, Issue 1, Pages 140-145Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.05.138
Keywords
Carcinoma cells; Cyclin A2; G1 arrest; Phenanthroindolizidine; Tylophora; Tylophorine
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Funding
- National Health Research Institutes, Taiwan [BP-094-PP-04, BP-095-PP-04, BP-096-PP-05, BP-097-PP-05]
- National Science Council of Taiwan [95-320-B-400-010-MY3]
- National Tsing Hua University
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Tylophorine, a representative phenanthroindolizidine alkaloid from Tylophora indica plants, exhibits anti-inflammatory and anti-cancerous growth activities. However, the underlying mechanisms of its anti-cancer activity have not been elucidated and its effects on cell cycle remain ambiguous. Here, we reveal by asynchronizing and synchronizing approaches that tylophorine not only retards the S-phase progression but also dominantly arrests the cells at G1 phase in HepG2, HONE-1, and NUGC-3 carcinoma cells. Moreover, tylophorine treatment results in down regulated cyclin A2 expression and overexpressed cyclin A2 rescues the G1 arrest by tylophorine. Thus, we are the first to report that the downregulated cyclin A2 plays a vital role in G1 arrest by tylophorine in carcinoma cells. (C) 2009 Elsevier Inc. All rights reserved.
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