Journal
MICROBES AND INFECTION
Volume 3, Issue 8, Pages 655-677Publisher
ELSEVIER
DOI: 10.1016/S1286-4579(01)01421-6
Keywords
Bordetella pertussis; pertussis vaccine; protective immunity; Th1; Th2; Tr1 cell; immunological memory; immune subversion; neurological response
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Bordetella pertussis exploits extracellular and intracellular niches in the respiratory tract and a variety of immune evasion strategies to prolong its survival in the host. This article reviews evidence of complementary roles for cellular and humoral immunity in protection. It discusses the effector mechanisms of bacterial elimination, the strategies employed by the bacteria to subvert protective immune responses and the immunological basis for systemic and neurological responses to infection and vaccination. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
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