Effects of biogenic amines on growth and the incidence of proventricular lesions in broiler chickens

Biogenic amines have been implicated in a malabsorption syndrome characterized by decreases in feed efficiency and enlargement of the proventriculus. Two studies were conducted to determine the effects of two common biogenic amines, histamine (HIS) and cadaverine (CAD), on broiler growth and the incidence of pathologies associated with proventriculitis. In the first experiment, broiler chicks were fed diets containing 0, 0.01, 0.05, 0.1, and 0.2% HIS, and in the second experiment chicks were fed diets containing 0, 0.1, and 0.2% HIS, 0.1% CAD, or a combination of 0.1% HIS and 0.1% CAD. Histamine at 0.1 and 0.2% or the combination of HIS and CAD (0.1% each) reduced body weight and feed conversion at 21 d of age. Histamine (0.2%) or the combination of 0.1% HIS and 0.1% CAD increased the circumference of the gastric isthmus 14 and 16%, respectively, and the relative weight of the proventriculus by 21 and 36%, respectively. Histamine and CAD increased the total number, incidence, and severity of gizzard erosion and proventricular ulcers (plaques), and decreased the prominence of gastric papillae by 9 to 108%, depending on the lesion and level of biogenic amine. Dietary HIS (0.2%) increased putrescine by 91%, and spermidine by 41% in proventriculus, and dietary CAD increased tissue CAD to detectable levels. Analysis of 49 commercially available, animal by-product feedstuffs suggests that if biogenic amines were the singular cause of proventriculitis, the current industry levels of dietary animal protein (5 to 10%) would not compromise growth performance.