Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 22, Issue 7, Pages 376-384Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(00)01663-1
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The completion of the genomic sequences of numerous organisms from human and mouse to Caenorhabditis elegans and many microorganisms. and the definition of their genes provides a database to interpret cellular protein-expression patterns and relate them to protein function. Proteomics technologies that are dependent on mass spectrometry and involve two-dimensional gel electrophoresis are providing the main window into the world of differential protein-expression analysis. In this article, the limitations and expectations of this research field are examined and the future of the analytical needs of proteomics is explored.
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