Journal
TUMOR BIOLOGY
Volume 22, Issue 4, Pages 223-228Publisher
KARGER
DOI: 10.1159/000050620
Keywords
CA 125; MUC1; CEA; breast cancer; pleura affection
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The serum tumor markers CA 125, MUC1 and CEA were measured in 221 breast cancer patients over a period of 2 years, Patients examined on at least three occasions were included in the study. Thirty-three patients had increasing or continuously high concentrations of CA 125. Thirty (91%) of these had involvement of the pleura, either as pleural metastasis or metastasis in surrounding tissue i.e, bone structures in the thorax cavity or lung parenchyma. MUC1 and CEA were elevated in 27 (82%) and 24 (73%) of the 33 patients, respectively. Increased concentrations of these two markers did not relate to the site of metastasis. However, the three tumor markers complemented each other in detecting early metastases, Increased CA 125 was associated with metastasis in or near the pleura, and in stage IV breast cancer it was related to poor prognosis. Copyright (C) 2001 S. Karger AG Basel.
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