Journal
PEPTIDES
Volume 22, Issue 7, Pages 1037-1042Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0196-9781(01)00438-7
Keywords
forced swimming test; NK3 receptors; antidepressant action; naltrexone; mice
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The influence of the tachykinin NK3 receptor agonist, aminosenktide on the immobility in the forced swimming test was studied in mouse lines selectively bred for divergent magnitudes of stress-induced analgesia. The high analgesia (HA) line is known to display enhanced, and the low analgesia (LA) line displays reduced activity of the opioid system. Aminosenktide at doses of 125 mug/kg or 250 mug/kg intraperitoneally (IP) reduced, in naltrexone-reversible manner, the immobility more of opioid receptor-dense HA than of unselected mice, but was ineffective in the opioid receptor-deficient LA line. The effect of aminosenktide was quite similar to the antiimmobility action of desipramine (10 mg/kg IF), a prototypic antidepressant agent. None of the compounds increased animals' locomotion as found with an open field test; therefore their antiimmobility effect cannot be attributed to a change in general motility. The results claim that aminosenktide causes an antidepressant effect, and endogenous opioids are involved in this process. (C) 2001 Elsevier Science Inc. All rights reserved.
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