Journal
PEDIATRIC NEPHROLOGY
Volume 16, Issue 7, Pages 537-542Publisher
SPRINGER
DOI: 10.1007/s004670100602
Keywords
encephalopathy; tacrolimus; grey matter; white matter; transplantation
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Neurological complications post transplant have been described with the use of calcineurin inhibitors. Although tacrolimus may be a better immunosuppressant than cyclosporine, its neurological side effects may be worse. Two children, living-related kidney trans plant recipients, were treated with antibody induction, mycophenolate mofetil, prednisone, and tacrolimus. Soon after transplant, they each developed an encephalopathy, which when visualized by magnetic resonance imaging showed that it affected both white and grey matter of the brain. Although the encephalopathy was associated with the use of tacrolimus, there was a complete neurological recovery without cessation of the drug.
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