Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 383, Issue 1, Pages 1-3Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.03.086
Keywords
Gremlin; Bone morphogenetic protein-7; Diabetic nephropathy; Therapy
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Funding
- Scientific Research Foundation for Returned Scholars
- Ministry of Education of China [2008139]
- Natural Science Foundation of Hebei Province [C20080000940]
- Key Applied Basic Research Programs of Science [072761229]
- Technology Commission Foundation of Hebei Province and Health Commission of Hebei Province [08007]
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Specific therapies of diabetic nephropathy (DN) are not available, and Current treatment strategies are limited to management of blood glucose levels and control of hypertension. The re-activation of developmental programs in DN Suggests new potential therapeutic targets. Bone morphogenetic protein-7 (BMP-7) and its antagonist, Gremlin is revealed to be involved in renal development and diabetic nephropathy. This article reviews the changes of BMP-7 and Gremlin in diabetic kidney, the protective effects on diabetic nephropathy when targeting BMP-7 and Gremlin, and the possible mechanism. The reorganization of the re-activation of Gremlin and BMP-7 in diabetic kidney had shed light on the identification of novel therapeutic targets for DN. (C) 2009 Elsevier Inc. All rights reserved.
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