Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 381, Issue 4, Pages 459-461Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.02.111
Keywords
Vasculitis; Intercellular adhesion molecule-1; Inflammation; Therapy
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Funding
- Natural Scientific Foundation of Jiangsu Province [BK2006727]
- New Century Excellent Talents [NCET-06-0507]
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Vasculitis is becoming more common worldwide, but there is no effective therapeutic method towards this series of disease till now. Intercellular adhesion molecule (ICAM)-1 is one of an important cell adhesion molecules (CAMs) family glycoprotein that plays pivotal role in inflammation process and participates in vasculitis. Blockade of ICAM-1 has been witnessed with its satisfactory effect on inflammatory disease treatment. Therefore, this method may be considered as a novel way towards treatment of vasculitis. (C) 2009 Published by Elsevier Inc.
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