Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 380, Issue 2, Pages 205-210Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2008.12.169
Keywords
MicroRNA; MiR-15b; Cell cycle; CCNE1; Glioblastoma
Categories
Funding
- Key Basic Research Developing Project [2007CB947001, 2006CB910104]
- State High Technology Developing Project [2008AA02Z115]
- Key Programs of National Science Foundation of China [30430240]
- Shanghai Metropolitan Fund for Research and Development [04DZI 4005, 04JC14096]
Ask authors/readers for more resources
MicroRNAs (miRNAs) are non-protein-cocling RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and glioma tissues from Chinese patients by miRNA microarray and identified a panel of differentially expressed miRNAs. Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its down stream targets. Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression ill glioma cells by targeting cell cycle-related molecules. (c) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available