Journal
JOURNAL OF BACTERIOLOGY
Volume 183, Issue 14, Pages 4389-4392Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.183.14.4389-4392.2001
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Funding
- NIGMS NIH HHS [R01 GM036718, GM36718] Funding Source: Medline
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The complete Bacillus subtilis genome contains four genes (proG, proH, proI, and comER) with the potential to encode Delta (1)-pyrroline-5-carboxylate reductase, a proline biosynthetic enzyme. Simultaneous defects in three of these genes (proG, proH, and proI) were required to confer proline auxotrophy, indicating that the products of these genes are mostly interchangeable with respect to the last step in proline biosynthesis.
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