Journal
NEUROBIOLOGY OF AGING
Volume 22, Issue 4, Pages 677-682Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0197-4580(01)00229-9
Keywords
alpha B-crystallin; ubiquitin; heat shock proteins; nonhuman primates; iron; Parkinson's disease; spheroids; Hallervorden-Spatz disease; oxidative stress
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Ubiquitin and alpha B-crystallin belong to a class of proteins which are overexpressed in a variety of human neuropathological conditions associated with increased cellular stress. In this study we have examined the brains of aged rhesus monkeys (Macaca mulatta; n = 10, mean age: 39.7 years) using antibodies against the stress proteins ubiquitin, alpha B-crystallin. and heat shock protein 27 (hsp27). Here, we demonstrate an increased expression of ubiquitin, alpha B-crystallin, and hsp27 in spheroid bodies predominantly localized in the globus pallidus and pars reticulata of the substantia nigra. A portion of the pallido-nigral spheroids also contained ferric iron as highlighted by Perls' staining. On the basis of these findings we advance the hypothesis that expression of ubiquitin, alpha B-crystallin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys represents a stress response possibly related to increased iron-mediated oxidative stress. (C) 2001 Elsevier Science Inc. All rights reserved.
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