Journal
MICROBES AND INFECTION
Volume 3, Issue 9, Pages 755-761Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S1286-4579(01)01423-X
Keywords
caveolae; lipid raft; endocytosis; microbes; toxin
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Funding
- NIAID NIH HHS [AI 35678] Funding Source: Medline
- NIDDK NIH HHS [DK 50814] Funding Source: Medline
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Many pathogens, including many traditionally extracellular microbes, now appear capable of entry into host cells with limited loss of viability. A portal of entry shared by some bacteria, bacterial toxins, viruses and parasites are caveolae (or lipid rafts), which are involved in the import and intracellular translocation of macromolecules in host cells. A requirement for caveolae-mediated endocytosis of microbes appears to be that the respective receptor is a constituent of caveolae or must move to caveolae following ligation. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
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