Journal
DIGESTIVE DISEASES AND SCIENCES
Volume 46, Issue 7, Pages 1387-1392Publisher
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/A:1010619316436
Keywords
cholangiocarcinoma; K-ras mutations; HER2/Neu; bFGF; TGF-beta; PDGF
Categories
Ask authors/readers for more resources
The expression of several growth factors and K-rns gene mutation in bile were studied to better understand the pathogenesis and improve early diagnosis of bile duct cancers. Bile samples were collected from 12 cholangiocarcinomas (CLC), 10 ampullary cancers (APC), 3 gallbladder cancers (GBC), 7 pancreatic cancers (PNC), 9 biliary tract infection (BTI), 8 biliary stone disease (ST), and 5 normal controls (NC), The highest mean value of TGF-P in bile was in patients with BTI, the mean levels of bFGF and PDGF were highest in CLC, and patients with APC and CLC had higher expression of HER2/Neu than other groups. In bile, a K-ras gene codon 12 mutation was found in 5 of 6 (83%) cases of CLC by the PCR-RFLP method. The results suggest overexpression of bFGF, PDGF. and MER2/Neu and the presence of K-ras mutation are important for carcinogenesis of bile duct cancers, and detection of the above abnormalities in bile is helpful for early diagnosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available