Journal
INFECTION AND IMMUNITY
Volume 69, Issue 7, Pages 4681-4685Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.7.4681-4685.2001
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Funding
- NIAID NIH HHS [R01 AI018045, R37 AI018045, AI-18045] Funding Source: Medline
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TolC and its homologues are outer membrane proteins that are essential for the transport of many molecules across the cell envelope. In this study we characterized the gene encoding Vibrio cholerae TolC. V. cholerae tolC mutants failed to secrete the RTX cytotoxin, were hypersensitive to antimicrobial agents, and were deficient in intestinal colonization.
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