Journal
JOURNAL OF PEDIATRICS
Volume 139, Issue 1, Pages 148-151Publisher
MOSBY-ELSEVIER
DOI: 10.1067/mpd.2001.115970
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Children and adults can have recurrent infection with invasive encapsulated bacterial pathogens such as Streptococcus pneumoniae as a result of a selective inability to respond to polysaccharide antigens. We have identified a mutation in the gene encoding Bruton's tyrosine kinase in a male patient with selective anti-polysaccharide antibody deficiency.
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