Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 365, Issue 1, Pages 149-153Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2007.10.138
Keywords
LEF-1; E2F1; transcription factor; reporter gene; histone deacetylase 1 (HDAC1)
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LEF-1 and E2F are both transcription factors involved in cell proliferation, differentiation and apoptosis. The present study shows for the first time that LEF-1 associates with E2F1 and further P-catenin independently activates the E2F-responsive reporter gene by attenuating the interaction between E2F1 and Histone deacetylase 1 (HDAC1), which indicates that LEF-1, except for its function in Writ signaling, may play a distinct role via activating the transcription of E2F1. (c) 2007 Elsevier Inc. All rights reserved.
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