Journal
SYNTHESIS-STUTTGART
Volume -, Issue 9, Pages 1341-1345Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2001-15229
Keywords
Biginelli reaction; lithium perchlorate; lithium triflate; dihydropyrimidinones
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Lithium perchlorate efficiently catalyzes the three-component condensation reaction of aldehyde, beta -keto ester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones in high yields under neutral conditional LiOTf is also found to be an efficient catalyst for the synthesis of dihydropyrimidinones from aldehyde, beta -keto ester and urea.
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