Journal
ACTA NEUROLOGICA SCANDINAVICA
Volume 104, Issue 1, Pages 44-47Publisher
MUNKSGAARD INT PUBL LTD
DOI: 10.1034/j.1600-0404.2001.00299.x
Keywords
acetazolamide; spinocerebellar ataxia type 6 (SCA6); ataxia rating scale; stabilometer
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Objective - To investigate the effect of acetazolamide on spinocerebellar ataxia type 6 (SCA6). Methods - Acetazolamide (250-500 mg/day) was administered orally for 88 weeks to 6 patients with SCA6, and its effect was quantitatively monitored using the Ataxia Rating Scale (ARS) and body sway analysis by stabilometry. Results - During administration of acetazolamide, the ARS score and the amplitude of body sway were significantly reduced compared with before administration. However, the response became weaker after 1 year of treatment. Conclusion - Although this was an open trial, the results suggested that acetazolamide can temporarily reduce the severity of symptoms during the progression of SCA6.
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