Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 291, Issue 5, Pages 2181-2195Publisher
ELSEVIER
DOI: 10.1074/jbc.M115.676510
Keywords
-
Categories
Funding
- National Basic Research Program of China [2011CBA01104, 2015CB943103, 2014CB964703]
- National Natural Science Foundation of China [31471289, 31030041]
Ask authors/readers for more resources
Acetoacetate (AA) is a ketone body and acts as a fuel to supply energy for cellular activity of various tissues. Here, we uncovered a novel function of AA in promoting muscle cell proliferation. Notably, the functional role of AA in regulating muscle cell function is further evidenced by its capability to accelerate muscle regeneration in normal mice, and it ameliorates muscular dystrophy in mdx mice. Mechanistically, our data from multiparameter analyses consistently support the notion that AA plays a non-metabolic role in regulating muscle cell function. Finally, we show that AA exerts its function through activation of the MEK1-ERK1/2-cyclin D1 pathway, revealing a novel mechanism in which AA serves as a signaling metabolite in mediating muscle cell function. Our findings highlight the profound functions of a small metabolite as signaling molecule in mammalian cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available