Journal
EUROPEAN JOURNAL OF HUMAN GENETICS
Volume 9, Issue 7, Pages 533-538Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.ejhg.5200659
Keywords
aneuploidy; paternal age; sex ratio; spermatozoa; FISH
Ask authors/readers for more resources
The aim of this study was to determine if donor age is associated with an increased incidence of diploidy and of disomy for the sex chromosomes and for chromosomes 6 and 21. We used simultaneous fluorescence in situ hybridisation (FISH) for chromosomes 6, 21, X and Y in sperm from 18 healthy donors, aged 24-74 years (mean 48.8 years). A total of 194 024 sperm were analysed, with a minimum of 10 000 sperm scored for each donor. Our results indicate a significant increase of the level of diploidy (P = 0.002), and a marginal significance of total sex chromosome disomy (P = 0.055) with age. No increase was observed for disomies XX, YY, XY, 21 or 6. The percentages of increase for disomy and for diploidy ranged from 0.3 to 17% for each 10-year period. Chromosomes 6 and 21 did not segregate preferentially with the X or Y chromosomes. Our findings show a linear trend association between age and diploidy inhuman males.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available