Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 21, Issue 4, Pages 235-252Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/A:1010958907271
Keywords
T-cell activation; potassium channel; calcium channel; immunosuppression; toxins; (patch-clamp)
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Funding
- NIGMS NIH HHS [GM41514] Funding Source: Medline
- NIMH NIH HHS [MH59222] Funding Source: Medline
- NINDS NIH HHS [NS14609] Funding Source: Medline
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The discovery of a diverse and unique set of ion channels in T lymphocytes has led to a rapidly growing body of knowledge about their functional roles in the immune system. Here we review the biophysical and molecular characterization of K+, Ca2+, and Cl- channels in T lymphocytes. Potent and specific blockers, especially of K+ channels, have provided molecular tools to elucidate the involvement of voltage- and calcium-activated potassium channels in T-cell activation and cell-volume regulation. Their unique and differential expression makes lymphocyte K+ channels excellent pharmaceutical targets for modulating immune system function. This review surveys recent progress at the biophysical, molecular, and functional roles of the ion channels found in T lymphocytes.
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