Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 58, Issue 8, Pages 1003-1013Publisher
SPRINGER BASEL AG
DOI: 10.1007/PL00000915
Keywords
neurotrophin; glial-derived neurotrophic factor; ciliary neurotrophic factor; structure; alignment
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The neutrophin family, the glial-derived neurotrophic factor family, and the ciliary neurotrophic factor are the best described growth factors specific for developing neurons and neutral crest cells. As might be expected for regulatory molecules of the complex central and peripheral nervous system, these factors show considerable receptor specificity and cross-talk. Thanks to a decade of intense research by numerous laboratories, the structures of many of these factors are now available. This review discusses the structural bases of receptor binding, specificity, and activation in each of these systems. Using structure-based sequence alignments, the evolutionary implications of these molecules and their receptors are discussed, followed by suggestions for further directions for research on the structure and function of these neurotrophic factors.
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