Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 49, Issue 1-2, Pages 189-198Publisher
ELSEVIER
DOI: 10.1016/S0169-409X(01)00134-X
Keywords
mitochondria; mitochondrial DNA; mitochondrial diseases; protein targeting; RNA transport; peptide transport; lipophilic cations
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Mitochondrial function is central to a range of cell processes and mitochondrial dysfunction contributes to a number of human diseases. Consequently there is growing interest in delivering large molecules such as nucleic acids, proteins, enzyme mimetics, drugs and probes to mitochondria within cells. The reasons for doing this are to understand how mitochondria function in the cell and to develop therapies for diseases involving mitochondrial damage. Here we review the methods that have been used to target large molecules to mitochondria and discuss some approaches under development. (C) 2001 Elsevier Science B.V. All rights reserved.
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