Journal
EMBO JOURNAL
Volume 20, Issue 13, Pages 3518-3525Publisher
OXFORD UNIV PRESS
DOI: 10.1093/emboj/20.13.3518
Keywords
GCF; imprinting; methylation
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The imprinted Igf2 gene is associated with a small upstream region that is differentially methylated on the active paternal allele, We have identified a repressor element within this sequence and shown that repression is probably mediated through a transacting factor, GCF2, DNA methylation of this site abrogates both protein binding and repressor activity. Targeting experiments demonstrate that this element plays a role in the repression of the maternal Igf2 gene in vivo.
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