4.4 Article

Catalytic asymmetric aldol reaction of ketones and aldehydes using chiral calcium alkoxides

Journal

TETRAHEDRON LETTERS
Volume 42, Issue 28, Pages 4669-4671

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)00819-X

Keywords

asymmetric aldol reaction; chiral Ca catalyst; CSI-MS; direct aldol reaction; hydrobenzoins

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A chiral hydrobenzoin/Ca complex catalyzes the reaction of acetophenone and aliphatic aldehydes to give the corresponding aldol products in up to 91% ee. (C) 2001 Elsevier Science Ltd. All rights reserved.

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