Journal
JOURNAL OF COMPARATIVE NEUROLOGY
Volume 435, Issue 4, Pages 464-473Publisher
WILEY
DOI: 10.1002/cne.1044
Keywords
neuritin; ligand; retinotectal; GPI; spinal cord; amphibian; plasticity; visual system
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Funding
- NEI NIH HHS [R29 EY011894-06, R29 EY011894] Funding Source: Medline
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Mechanisms controlling dendritic arbor formation affect the establishment of neuronal circuits. Candidate plasticity gene 15 (CPG15) is a glycosylphosphatidyl inositol (GPI)-linked activity-induced protein that has been shown to function as an intercellular signaling molecule that can promote the morphological and physiological development of the Xenopus retinotectal system. A thorough understanding of CPG15 function requires knowledge of the spatiotemporal expression of the endogenous protein. We therefore cloned Xenopus cpg15 and used RNA in situ hybridization and immunohistochemistry to determine the pattern of CPG15 expression. cpg15 mRNA and CPG15 protein are first detectable in the developing spinal cord and become widespread as development proceeds. CPG15 is expressed in sensory regions of the brain, including the visual, auditory, and olfactory systems. Within the retina, CPG15 is only expressed in retinal ganglion cells. CPG15 protein is concentrated in axon tracts, including retinal axons. These data support a model in which CPG15 expressed in retinal ganglion cells is trafficked to retinal axone, where it modulates postsynaptic dendritic arbor elaboration, and synaptic maturation. (C) 2001 Wiley-Liss, Inc.
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