Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 11, Issue 13, Pages 1775-1777Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00299-2
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A new pronucleotide series is described involving a two-step degradation process mediated by. respectively, carboxylesterase and phosphoramidase. Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK- cell line, which proves 5'-AZTMP delivery. (C) 2001 Elsevier Science Ltd. All rights reserved.
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