Journal
JOURNAL OF CONTROLLED RELEASE
Volume 75, Issue 1-2, Pages 55-67Publisher
ELSEVIER
DOI: 10.1016/S0168-3659(01)00365-0
Keywords
temperature-modulated drug delivery systems thermoresponsive hydrogel; N-isopropylacrylamide; thermoresponsive membrane; cryo-scanning electron microscopy
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A novel thermoresponsive composite membrane is described through which the permeation of molecules is dependent on the temperature of the milieu. The thermoresponsive composite membranes utilise a thermosensitive crosslinked polymeric hydrogel, which possesses a volume phase transition temperature (VPTT). The hydrogel was polymerised in situ within the pores of a sintered glass filter, through which significant permeation of molecules only occurred at temperatures above the VPTT of the hydrogel. It was found that the permeation of molecules through the thermoresponsive composite membranes could be modulated by changing the environmental temperature. (C) 2001 Elsevier Science BY All rights reserved.
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