A new multicomponent domino reaction of 1,3-dicarbonyl compounds:: One-pot access to polycyclic N/O-, N/S-, and N/N-aminals

[GRAPHICS] The first multicomponent domino transformation between 1,3 dicarbonyls 1, alpha,beta -unsaturated compounds 2, and functionalized amines 3 is described, providing a one-pot access to fused polyheterocyclic or spiropolyheterocyclic compounds 5 or 6 bearing an aminal function by formation of up to three new cycles, five novel bonds, and up to six stereogenic centers.