Journal
ORGANIC LETTERS
Volume 3, Issue 14, Pages 2169-2171Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol015985j
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- NCI NIH HHS [P01 CA48112] Funding Source: Medline
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[GRAPHICS] Aiphanol (1), a novel stilbenolignan, along with isorhapontigenin (2), piceatannol (3), and luteolin, were isolated by bioassay-guided fractionation from the seeds of Aiphanes acoleata Willd. (Arecaceae). The structure of compound 1 was elucidated by spectroscopic methods. Compound 1 is based on an unprecedented stilbenolignan skeleton in which a stilbene moiety is linked with a phenylpropane unit through a dioxane bridge. Compounds 1 and 2 exhibited significant inhibitory activities against cyclooxygenases-1 and -2.
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