Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 285, Issue 2, Pages 546-549Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2001.5138
Keywords
vitamin A; IgA; IL-4; IL-5; IL-6; small intestinal mucose; IL-5 receptor alpha-chain-deficient mice; cholera toxin
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To clarify actions of vitamin A on mucosal immunity associated with interleukin-5 (IL-5), we examined effects of vitamin A on mucosal IgA level in IL-5 receptor alpha -chain-knockout (IL-5R alpha (-/-)) mice. Daily supplementation of retinyl acetate (1 mg/mouse) increased Th2 cytokine levels and a number of their positive cells in the small intestinal mucosa of IL-5R alpha (-/-) mice, as observed in wild-type or IL-5R alpha (+/-) mice. Wild-type and heterozygous mice increased the IgA level and a number of IgA-containing cells in the mucosa in response to the vitamin A treatment, but not in IL-5R alpha (-/-) mice. Retinyl acetate increased anti-cholera toxin (CT) IgA level in the mucosa of wild-type mice, improving their survival rate after an exposure to 0.4 mg of CT. However, retinyl acetate failed to induce resistance to CT toxicity in IL-5R alpha (-/-) mice. Our results suggest that IL-5 may play an important role in an action of vitamin A on mucosal IgA system. (C) 2001 Academic Press.
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