Journal
MOLECULAR BRAIN RESEARCH
Volume 91, Issue 1-2, Pages 34-42Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(01)00116-4
Keywords
rat retina; NMDA; cDNA array; AIP
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Calcium/calmodulin-dependent protein kinase II containing a nuclear localizing signal (CaMKII-alpha (B)) is altered in retinal neurons exposed to N-methyl-D-aspartate (NMDA). AIP (myristoylated autocamtide-2-related inhibitory peptide), a specific inhibitor of CaMKII provides neuroprotection against NMDA-mediated neurotoxicity. In this: study, gene-arrays were used to investigate which apoptosis-associated genes are altered after exposure to NMDA. The data indicate an increased expression (2-7-fold) of five such genes encoding proteins that could be involved in NMDA induced cell death. The up-regulated genes are: FasL; GADD45; GADD153; Nur77 and TNF-R1. Treatment with AIP blocked their altered expression. The results suggest that multiples genes are involved in NMDA-induced excitotoxicity and that AIP, a specific inhibitor for CaMKII, regulates the expression of these apoptosis-associated genes in the retina. (C) 2001 Published by Elsevier Science B.V.
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