Journal
GENES & DEVELOPMENT
Volume 15, Issue 14, Pages 1759-1764Publisher
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.897901
Keywords
Cdh1; APC; MAD2; MAD2L2; ubiquitin; checkpoint
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Funding
- NIGMS NIH HHS [GM39023, GM26875, R01 GM039023, R01 GM026875] Funding Source: Medline
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Exit from mitosis requires the degradation of regulatory proteins including the mitotic cyclins and securin through ubiquitination by the anaphase promoting complex (APC) bound to Cdc20 or Cdh1. Cdc20-APC is regulated through inhibition by the spindle assembly checkpoint protein MAD2. Knowledge of Cdh1-APC regulation is limited to the phosphorylation-dependent dissociation of Cdh1 from APC. We report a novel means of regulating Cdh1 by the MAD2-related gene, MAD2L2. MAD2L2 specifically binds and inhibits Cdh1-APC, paralleling the effect of MAD2 on Cdc20. We suggest that MAD2L2 and MAD2 inhibit the release of substrates from APC and propose a mechanism of inhibition.
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