Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 194, Issue 2, Pages 165-172Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.194.2.165
Keywords
IL-4; IL-12; differentiation; commitment; cell cloning
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Funding
- NIAID NIH HHS [K22 AI01663-02] Funding Source: Medline
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T helper cell (Th)1-primed CD4 T cells from wild-type donors make little interleukin (IL)-4 when restimulated under Th2 conditions. However, such restimulation of Th1-primed cells from interferon (IFN)-gamma (-/-) or IFN-gamma receptor (IFN-gammaR)(-/-) mice resulted in substantial production of IL-4 and other Th2 cytokines. Adding IFN-gamma to the priming culture markedly diminished the capacity of Th1-primed IFN-gamma (-/-) cells to express IL-4. Even IFN-gamma -producing cells from IFN-gammaR(-/-) mice could acquire IL-4-producing capacity. Thus, IFN-gamma is not required for the development of IFN-gamma -producing capacity, but it plays a critical role in suppressing the IL-4-producing potential of Th1 cells.
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