Journal
VACCINE
Volume 19, Issue 28-29, Pages 3870-3876Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(01)00127-X
Keywords
hemagglutinin; immune responses; rinderpest
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Rinderpest virus causes a highly contagious and often fatal disease in domestic and wild ruminants. The surface glycoproteins, hemagglutinin (H) and fusion (F) proteins of this enveloped virus are known to confer protective immunity in cattle. We have reported the generation of a recombinant baculovirus expressing H protein and studied its protective properties in cattle. In this report, we demonstrate that the recombinant baculovirus encoded H protein expressed in insect cells gets incorporated into extracellular baculovirus. Single administration of low doses of purified recombinant extracellular virus with or without adjuvant induces virus neutralizing antibody responses and bovine leukocyte antigen (BoLA) class II restricted helper T cell responses in cattle. (C) 2001 Elsevier Science Ltd. All rights reserved.
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