Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 194, Issue 2, Pages 189-203Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.194.2.189
Keywords
infertility; signal transduction; STAT; interleukin; gene targeting
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The receptor subunit gp130 transduces multiple cell type-specific activities of the leukemia inhibitory factor (LIF)interleukin (IL)-6 family of cytokines through the signal transducer and activator of transcription (STAT) and src homology 2 domain-bearing protein tyrosine phosphatase (SHP)-2/ras/Erk pathways. To define STAT-dependent physiological responses, we generated mice with a COOH-terminal gp130(Delta STAT) knock-in mutation which deleted all STAT-binding sites, gp130(Delta STAT) mice phenocopyed mice deficient for IL-6 (impaired humoral and mucosal immune and hepatic acute phase responses) and LIF (failure of blastocyst implantation). However, unlike mice with null mutations in any of the components in the gp130 signaling pathway, gp130(Delta STAT) mice also displayed gastrointestinal ulceration and a severe joint disease with features of chronic synovitis, cartilaginous metaplasia, and degradation of the articular cartilage. Mitogenic hyperresponsiveness of synovial cells to the LIF/IL-6 family of cytokines was caused by sustained gp130-mediated SHP-2/ras/Erk activation due to impaired STAT-mediated induction of suppressor of cytokine signaling (SOCS) proteins which normally limits gp130 signaling. Therefore, the joint pathology in gp130(Delta STAT) mice is likely to arise from the disturbance of the otherwise balanced activation of the SHP-2/ras/Erk and STAT signaling cascades emanating from gp130.
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