Journal
NEUROREPORT
Volume 12, Issue 10, Pages 2255-2258Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200107200-00042
Keywords
calcium influx; glutamate release; lamotrigine; synaptosomes
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Lamotrigine (LAG) is an antiepileptic drug which is believed to suppress seizures by inhibiting the release of excitatory neurotransmitters. The present study was aimed at investigating the effect of LAG on the 4-aminopyridine (4AP)-evoked glutamate release in cerebrocortical nerve terminals (synaptosomes). LAG inhibited the release of glutamate evoked by 4AP in a concentration-dependent manner. This inhibitory effect was associated with a reduction in the depolarization-evoked increase in the cytoplasmic free Ca(2+) concentration ([Ca(2+)]c).
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