Journal
NEUROREPORT
Volume 12, Issue 10, Pages 2131-2136Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200107200-00018
Keywords
anandamide; cannabinoid; CB1 receptor; phospholipase C; rapid eye movement sleep
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Anandamide (ANA) alters sleep by increasing the amount of time spent in slow wave sleep 2 (SWS2) and rapid eye movement sleep (REMS) at the expense of wakefulness (W) in rats. In this report, we describe a similar effect of ANA when injected itracerebroventricularly (i.c.v.) or into the peduriculo-pontine tegmental nucleus (PPTg) and the lack of an effect when ANA is administered into the medial preoptic area (MPOA). Furthermore, the i.c.v. or PPTg administration of SR141716A, a CB1 antagonist, or U73122, a PLC inhibitor, 15 min prior to ANA, readily prevents the ANA induced changes in sleep. The present results suggest that a cannabinoid system in the PPTg may be involved in sleep regulation and that the cannabinoid effect is mediated by the CB1 receptor coupled to a PLC second messenger system. NeuroReport 12:2 131-2136 (C) 2001 Lippincott Williams & Wilkins.
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