Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 11, Issue 14, Pages 1869-1870Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00348-1
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Cephalosporins with an alpha -amino group on the 7-beta -acyl substituent have been shown to undergo aminolysis with subsequent formation of a fluorescent pyrazinone degradation product. An analogous reaction seems to take place upon in vitro conjugation of such cephalosporins to albumins and polylysine. A corresponding pyrazinone-polylysine conjugate was able to bind IgE antibodies in sera from patients with suspected allergy to p-lactams. These findings may have applications in the diagnosis of allergy against aminocephalosporins. (C) 2001 Elsevier Science Ltd. All rights reserved.
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