Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1540, Issue 1, Pages 1-21Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-4889(01)00123-9
Keywords
focal adhesion kinase; integrin; Src; Rho; migration; apoptosis; cancer
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Funding
- NCI NIH HHS [CA90901] Funding Source: Medline
- NIGMS NIH HHS [GM57943] Funding Source: Medline
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The focal adhesion kinase, FAK, is an important component of an integrin-dependent signaling pathway, which functions to transmit signals from the extracellular matrix into the cytoplasm. FAK is an essential gene product, since the fak-/-mouse exhibits embryonic lethality. A number of important biological processes, including cell motility and cell survival, are controlled by integrin-dependent signals and FAK has been implicated in regulating these processes. This review will focus upon recent findings providing insight into the mechanisms by which FAK transmits biochemical signals and elicits biological effects. (C) 2001 Elsevier Science B.V. All rights reserved.
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