Journal
LANCET
Volume 358, Issue 9278, Pages 298-300Publisher
LANCET LTD
DOI: 10.1016/S0140-6736(01)05499-X
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OLIG2 is a recently Identified transcription factor involved In the specification of cells In the oligodendroglial lineage. We Investigated the expression of OLIG2 by In-situ hybridisation In 21 brain tumours: nine grade II and III oligodendrogliomas, three grade II oligoastrocytomas, and nine non-oligodendroglial tumours (four grade IV astrocytomas, two meningiomas, a dysembryoplastic neuroepithelial tumour, and two metastases). OLIG2-positive cells corresponding to neoplastic oligodendrocytes were present in all oligodendrogliomas and oligoastrocytomas. By contrast, OLIG2 expression was not detected in the non-oligodendroglial tumours. Thus, oligodendroglioma probably arise from oligodendrocyte precursor cells. OLIG2 should prove a useful marker for the diagnosis of oligodendroglial tumours.
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