Journal
TETRAHEDRON LETTERS
Volume 42, Issue 31, Pages 5223-5225Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)00984-4
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The enantioselective synthesis of trans-(2R,3R)-3-hydroxypipecolic acid Ib is presented, starting from O-protected methyl mandelate as chiral source. The synthesis involved a regioselective intramolecular nucleophilic substitution of an azido epoxide as the key step. (C) 2001 Elsevier Science Ltd. All rights reserved.
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