Journal
JOURNAL OF MASS SPECTROMETRY
Volume 36, Issue 8, Pages 849-865Publisher
WILEY
DOI: 10.1002/jms.207
Keywords
time-of-flight mass spectrometry; quadrupole mass spectrometry; collision-induced dissociation; electrospray; matrix-assisted laser desorption/ionization
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A brief introduction is presented to the basic principles and application of a quadrupole-time-of-flight (TOF) tandem mass spectrometer. The main features of reflecting TOF instruments with orthogonal injection of ions are discussed. Their operation and performance are compared with those of triple quadrupoles with electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) TOF mass spectrometers. Examples and recommendations are provided for all major operational modes: mass spectrometry (MS) and tandem MS (MS/MS), precursor ion scans and studies of non-covalent complexes: Basic algorithms for liquid chromatography/MS/MS automation are discussed and illustrated by two applications. Copyright (C) 2001 John Wiley & Sons, Ltd.
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