Journal
IMMUNOLOGICAL REVIEWS
Volume 182, Issue -, Pages 201-206Publisher
WILEY
DOI: 10.1034/j.1600-065X.2001.1820116.x
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Funding
- NIAID NIH HHS [2R01AI25210-14] Funding Source: Medline
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Human CD8(+)CD28(-) suppressor T cells (Ts) are a subset of T cells generated in the course of in vitro and in vivo immunizations. Ts recognize MHC class I:peptide complexes and inhibit the reactivity of T helper cells (Th) with cognate antigen specificity. We have demonstrated for the first time that CD8(+)CD28(-) Ts represent a unique subset of regulatory cells that induces the differentiation of tolerogenic antigen-presenting cells, initiating a Suppressive loop which results in the induction and spreading of Th unresponsiveness.
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