Journal
CURRENT OPINION IN NEUROLOGY
Volume 14, Issue 4, Pages 423-432Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00019052-200108000-00001
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- NIA NIH HHS [AG17216-1, AG03949-13, AG14449-2] Funding Source: Medline
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alpha -Synuclein has risen to prominence during the past 5 years because of its association with several neurodegenerative diseases that have come to be known as the synucleinopathies: The clinical phenotype of the synucleinopathies is variable, with the most common being parkinsonism, autonomic dysfunction, and dementia. Progress has been made in clinical, neuropathologic and biochemical characterization of the synucleinopathies and their differentiation from other neurodegenerative disorders. At the molecular level, the synucleinopathies have conformational and post-translational modifications of synuclein that favor its fibrillization and aggregation in inclusions in neurons and glia. Whether inclusion body formation is an adaptive response or is directly related to degeneration of neuronal and glial cells is a topic of current research. Curr Opin Neurol 14:423-432. (C) 2001 Lippincott Williams & Wilkins.
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