Journal
TRENDS IN IMMUNOLOGY
Volume 22, Issue 8, Pages 443-449Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(01)01976-7
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Funding
- NIAID NIH HHS [AI48120, AI36529] Funding Source: Medline
- NIAMS NIH HHS [F32 AR47759] Funding Source: Medline
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It is estimated that 50-90% of the proteins in the human body are posttranslationally modified. In the proper context, these modifications are necessary for the biological functions of a vast array of proteins and the effector functions of the cells in which they reside. However, it is now clear that some post-translational modifications can create new self antigens (Ags) or even mask Ags normally recognized by the immune system. In either case,they profoundly affect the recognition of Ag by bone marrow-derived cells, as well as their effector functions. How do post-translational protein modifications affect the processing of foreign and self Ags and what is their role in the origin of autoimmune responses?
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