Journal
CELLULAR IMMUNOLOGY
Volume 211, Issue 2, Pages 131-142Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/cimm.2001.1829
Keywords
Burkitt's lymphoma; Epstein-Barr virus; IL-4; IL-13; IL-13 receptor; JAK/STAT6
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IL-4 and IL-13, cytokines with similar biological effects may influence growth and progression of B-cell tumors through regulation of key cell surface molecules important in intercellular communications. In this study, we demonstrate that IL-4 and IL-13 exhibited differential effects on CD23 and CD44 expression and binding to hyaluronan in BL30/B95-8, a Burkitt's lymphoma (BL), and MK3.31, an Epstein-Barr virus transformed normal human B cell line (B-LCL). Studies conducted to understand the molecular mechanisms underlying this differential effect show that IL-4 induced phosphorylation of JAK1, JAK3, and STATE in BL30/B95-8 cells and of JAK3 and STATE in MK 3.31 cells. In contrast, IL-13 failed to induce the phosphorylation of JAK kinases or STATE proteins in these cell lines. The inability of BL30/B95-8 cells to respond to IL-13 was attributed to the loss of expression of IL-13R subunits alpha1 and alpha2, a finding confirmed for a number of other BL cell lines examined. (C) 2001 Academic Press.
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