Journal
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
Volume 22, Issue 5, Pages 863-882Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.berh.2008.09.010
Keywords
Churg-Strauss syndrome; eosinophilia; hypereosinophilic syndrome; mepolizumab; physiopathology; treatment; tyrosine kinase
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Hypereosinophilia (>0.5 x 10(9)/L) is a common clinical finding that can be secondary to a large variety of diseases (helminth infections, allergic diseases, drug reactions, specific organ disease, malignancies, systemic diseases). When a complete evaluation of a chronic hypereosinophilia fails to reveal an underlying disease, the diagnosis of hypereosinophilic syndrome (HES) or Churg-Strauss syndrome (CSS) is suggested.
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